An Overview of the Resistance Mechanisms Against RAS-Targeted Drugs Beyond G12C

Time: 12:00 pm
day: Day One Track B AM


  • Understanding the resistance profiles of different KRAS mutants to effectively target each mutation
  • Differentiating resistance based on mechanism of action to devise the most effective treatment regimen and potential lines of treatment
  • Combining the resistance profiles with histotype analysis of associated cancers for each mutation to create a holistic resistance profile
  • Exploring feasibility of combination therapies based on validated molecular resistance mechanisms