Nicholas Endres

Company: Genentech

Job title: Scientist

Seminars:

Introducing SOS-Independent Inhibition of KRAS G13D with a Switch-2 Inhibitor to Unlock Targeting Codon 13 Mutations 4:15 pm

Revealing how KRAS G13D is expected to be hard to target with switch-2 inhibitors due to its high intrinsic exchange rate, which makes it less dependent on SOS for activation in cells. Showcasing how a switch-2 inhibitor can not only blocks SOS exchange but also reduces intrinsic exchange rates of KRAS G13D to levels comparable…Read more

day: Conference Day One