RAS 101: Understanding the RAS Pathway & Its Oncogenic Mutations to Improve Drug Discovery & Design
Time: 9:01 am
day: Workshop A
Details:
The RAS/MAPK pathway is an extremely important signalling cascade that plays a major role in
driving oncogenesis. It stretches from receptors on the cell membrane to transcription factors in
the nucleus and is naturally robust to prevent disruption. Hence, to effectively target RAS and its
surrounding molecules for effective cancer therapy, it is important to understand the basic biology
of Wild-Type RAS, as well as the idiosyncrasies of its various mutations.
This workshop will:
- Provide an in-depth understanding of the basic biology of the RAS/MAPK Pathway to highlight
- targetable nodes
- Present a complete overview of the various oncogenic mutations that occur to understand RAS’
- role in oncogenesis
- Take a deeper look at protein prenylation in the RAS pathway as a targetable node
