Make it a Combo Meal: Exploring Combination Therapies that Assist RAS-Targeted Drugs in Ensuring Cancer Free Survival
Time: 3:01 pm
day: Workshop C
Details:
Given the RAS pathway’s importance to normal cell homeostasis, it has evolved to be a naturally
robust pathway that is difficult to disrupt. For a few years now, it has become clear that RAStargeted
drugs work more effectively when combined with other therapies, such as inhibitors up/
downstream of RAS, immune checkpoint inhibitors and various IO strategies among others.
However, optimal combinations are complicated to construct as they are affected by drug design,
the cancer histotype and patient profile to name just a few factors. Hence, it is important to assess
the results from various combinations to create effective frontline RAS therapies for cancer.
This workshop will:
- Evaluate various combination therapy possibilities to elucidate the range of treatment options for RAS addicted cancers
- Examine pre-clinical and clinical data on combination therapies to tease out the patterns in efficacy
- Leverage strategies to effectively apply the patterns to support designing combination therapy regimens
