Leveraging Systems Biology & Pharmacology Tools to Elucidate RAS Regulatory Networks & Reveal New Therapeutic Targets
Time: 11:30 am
day: Workshop C
Details:
Systems biology and pharmacology has increasingly become instrumental in dissecting complex RAS networks including vertical and parallel pathways. However the entire RAS interactome is yet to be elucidated leaving untapped opportunity to overcome acquired resistance, inform combination strategies and target previously undrugged mutations and isoforms. This workshop will explore the molecular biology, omics and pharmacology tools used to elucidate RAS pathways and noncanonical approaches to target the broader oncogenic RAS landscape.
This workshop will discuss:
• What do we know about RAS networks, and what further dissection of pathways and interaction networks is needed?
• What is the utility of implementing quantitative multiplexed proteomics and how does this elucidate the RAS interactome? How can these assays inform combination therapies?
• How to leverage genomics, molecular biology and pharmacology tools to elucidate non-canonical approaches to target oncogenic RAS?
• What is the scope targeting non-oncogene addiction?
