Translating Variant-Selective, Pan-RAS, and Combination Innovations into Robust, Potent Therapies Delivering Meaningful Clinical Benefit Across RAS-Driven Tumors
RAS-targeted drug development has entered a pivotal new phase. Once considered “undruggable,” RAS is now one of oncology’s most competitive and fast-moving therapeutic frontiers, with next-generation inhibitors, pan-RAS strategies, novel modalities, and complex combination approaches advancing in parallel. As programmes expand beyond G12C into G12D, G12V, G13D, and multi-variant targeting, the challenge has shifted from discovery to delivering durable clinical impact.
The 8th RAS-Targeted Drug Development Summit is the industry’s only forum dedicated exclusively to translating RAS therapies from early discovery through clinical development. Bringing together leaders across biopharma, including Bristol Myers Squibb, Amgen, Revolution Medicines, Verastem, Incyte, Jacobio Pharmaceuticals and NCI the meeting focuses on overcoming resistance, improving therapeutic durability, and accelerating development timelines.
Join senior RAS-focused experts to gain actionable insights on next-generation targeting strategies, innovative modalities, smarter combination design, and precision patient stratification, equipping you to advance more effective RAS therapies for broader patient populations.
As the field of RAS-targeted therapies continues to evolve rapidly, this meeting plays an important role in bringing together leaders across academia, biotech, and industry to exchange perspectives and align on the key scientific and clinical challenges ahead.
Ivana Sullivan, Clinical Research Medical Director, Amgen
The meeting provides a platform to discuss an aspect of cancer biology that has been challenging to address. Finally, we are seeing promising advancements that have the potential to transform patient outcomes across multiple difficult to treat cancers.
Mani Mohindru, Chief Executive Officer, Cardiff Oncology
Thought leaders in the field will convene into a focused forum aimed at removing current obstacles on the development and clinical uptake of RAS inhibitors, with the ultimate goal of improving durability of response and safety of RAS inhibitors, extending the life of patients further.
Federico Innocenti, Senior Director, Clinical Development, Solid Tumors, BeOne Medicines
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