Said Sebti
Professor, Virginia Commonwealth University, Scientific Co- Founder Prescient Therapeutics
Seminars
Tuesday 16th September 2025
FGTI-2734 Overcomes KRAS G12C & KRAS G12D Inhibitor Resistance by Suppressing ERK Reactivation
2:15 pm
- FGTI-2734 blocks RAS membrane localization and ERK reactivation, key mechanisms of resistance to sotorasib in KRAS G12C lung cancer
- FGTI-2734 synergizes with sotorasib to inhibit cell viability and induce apoptosis, including in sotorasib-resistant KRAS G12C lung cancer cells
- In xenograft and patient-derived models, FGTI-2734 enhances sotorasib efficacy, overcoming resistance and driving significant tumor regression
