Said Sebti

Professor, Virginia Commonwealth University, Scientific Co- Founder Prescient Therapeutics

Seminars

Tuesday 16th September 2025
FGTI-2734 Overcomes KRAS G12C & KRAS G12D Inhibitor Resistance by Suppressing ERK Reactivation
2:15 pm
  • FGTI-2734 blocks RAS membrane localization and ERK reactivation, key mechanisms of resistance to sotorasib in KRAS G12C lung cancer
  • FGTI-2734 synergizes with sotorasib to inhibit cell viability and induce apoptosis, including in sotorasib-resistant KRAS G12C lung cancer cells
  • In xenograft and patient-derived models, FGTI-2734 enhances sotorasib efficacy, overcoming resistance and driving significant tumor regression

Said Sebti (1)