Dhirendra Simanshu

Company: Frederick National Laboratory for Cancer Research

Job title: Principal Scientist & Group Lead - Structural Biology

Seminars:

Distinctive Properties of KRAS4a and KRAS4b Splice Variants & Therapeutic Considerations 5:15 pm

KRAS4a shows high transcriptional activity in bile ducts, liver, and stomach, approaching KRAS4b levels in the colon and rectum. Comparative analysis of KRAS4a and KRAS4b revealed distinct structural properties and thermal stability. Functional disparities in full-length KRAS splice variants highlight HVR variations' impact on interactions with trafficking proteins and downstream effectors.Read more

day: Conference Day One