Dhirendra Simanshu

Dhirendra Simanshu

Company: Frederick National Laboratory for Cancer Research

Job title: Principal Scientist - Structural Biology, RAS Initiative & Group Lead


Structure of the SHOC2-MRAS-PP1C Complex Provides New Insights into RAF Activation & Drug Development Against RAS-Driven Cancers 4:00 pm

Dephosphorylation of a specific phosphoserine on RAF kinases by a heterotrimeric SMP complex formed by SHOC2, MRAS, and PP1C provides critical activating input The Heterotrimeric SMP complex is a therapeutic target for ERK pathway inhibition in RAS-driven cancers Our work provides structural insights into the role of the heterotrimeric complex in RAF activation and new…Read more

day: Day Two Track D

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