Dhirendra Simanshu
Group Lead RAS Initiative, Frederick National Laboratory
Seminars
Thursday 18th September 2025
LZTR1 Interaction with RAS GTPases Provides Insight into RAS Degradation
9:30 am
- LZTR1 targets GDP-bound RAS proteins for degradation via the Cul3 ubiquitin ligase
- Loss of LZTR1 in cancer increases Rit1 and other RAS proteins, sustaining MAPK signaling
- Harnessing LZTR1 offers a potential strategy to degrade oncogenic RAS therapeutically
