Dhirendra Simanshu

Group Lead RAS Initiative, Frederick National Laboratory

Seminars

Thursday 18th September 2025
LZTR1 Interaction with RAS GTPases Provides Insight into RAS Degradation
9:30 am
  • LZTR1 targets GDP-bound RAS proteins for degradation via the Cul3 ubiquitin ligase
  • Loss of LZTR1 in cancer increases Rit1 and other RAS proteins, sustaining MAPK signaling
  • Harnessing LZTR1 offers a potential strategy to degrade oncogenic RAS therapeutically
Dhirendra Simanshu