Roundtable Discussion: Comparing On vs. Off-State Approaches in the Targeting of RAS for Achieving More Durable & Efficacious Responses
- How to achieve high specificity and affinity given the highly dynamic and flexible structures of the on- and off-states of RAS?
- Does targeting active or inactive states of RAS lead to more durable and tolerable treatments of cancer?
- Investigating the key challenges of targeting the active vs inactive states of RAS