Discovery of a Novel Molecular Glue Degrader Engaging a New E3 Ligase to Target KRAS Mutants & C-RAF
- Discovery of a novel small-molecule glue degrader with selectivity for KRAS mutants over KRAS WT
- Identification of a new E3 ligase pathway independent of the Cullin-RING system
- Dual degradation of mutant KRAS in complex with C-RAF