Samuel Wickline

Samuel Wickline

Company: Altamira Therapeutics

Job title: Chief Scientific Officer

Seminars:

Extrahepatic Nucleotide Delivery with Self-Assembling Peptide-Based Nanostructures for RNAi against KRAS 1:30 pm

Self-assembling peptide-nucleotide (siRNA, mRNA) polyplexes avoid sequestration in liver, track to myriad pathologies, but do not distribute to tissues/organs with normal vascular barriers Following cell uptake, the peptide moiety itself facilitates rapid and complete endosomal escape and KRAS siRNA release into cytoplasm to inhibit KRAS production Peptide-nucleotide polyplexes are safe and stable in circulation, cleared…Read more

day: Day One Track A

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