Diana Marcantonio

Diana Marcantonio

Company: Applied BioMath

Job title: Senior Principal Scientist

Seminars:

Application of a quantitative systems pharmacology model to support differentiation of ASP2453, a novel KRASG12C inhibitor 1:00 pm

KRASG12C mutations lead to constitutive proliferation signaling and are prevalent across human cancers. Sotorasib, a KRASG12C inhibitor, was recently approved for the treatment of KRASG12C-mutated locally advanced or metastatic non-small cell lung cancer, and several other KRASG12C inhibitors are in clinical trials.  ASP2453 is a novel, highly-potent, and selective inhibitor of KRASG12C. Will ASP2453 show a more…Read more

day: Day One Track B

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