Targeting RAS Mutations & MAPK Pathway Aberrations via Vertical Combination
Time: 5:30 pm
day: Day One Track I
Details:
- Vertical combination represents a useful approach to target the MAPK pathway aberrations including RAS mutations
- The synergistic activity from inhibition of the different nodes of the MAPK pathway leads to more complete and sustained pathway inhibition
- Inhibition of multiple nodes of the pathway suppresses the feedback activation of upstream signalling and potentially delay the development of drug resistances
- Preclinical and clinical data of several vertical combinations support using this strategy to target MAPK pathway aberrations including RAS mutations
