Structure of the SHOC2-MRAS-PP1C Complex Provides New Insights into RAF Activation & Drug Development Against RAS-Driven Cancers

Time: 4:00 pm
day: Day Two Track D


  • Dephosphorylation of a specific phosphoserine on RAF kinases by a heterotrimeric SMP complex formed by SHOC2, MRAS, and PP1C provides critical activating input
  • The Heterotrimeric SMP complex is a therapeutic target for ERK pathway inhibition in RAS-driven cancers
  • Our work provides structural insights into the role of the heterotrimeric complex in RAF activation and new avenues for therapeutic interventions