NS1 Monobody Targeting the α4-α5 Allosteric Interface of RAS Inhibits Tumorigenesis In Vivo

Time: 4:30 pm
day: Day One Track G


  • NS1 Monobody binds to dimer interface of RAS
  • NS1 blocks RAS self-association that in turn impairs BRAF/CRAF heterodimerization
  • The intrinsic cell inhibition of mutant KRAS changes the phenotype of otherwise immunologically cold PDAC tumors by increasing infiltration of T cells