Extrahepatic Nucleotide Delivery with Self-Assembling Peptide-Based Nanostructures for RNAi against KRAS
Time: 1:30 pm
day: Day One Track A
Details:
Self-assembling peptide-nucleotide (siRNA, mRNA) polyplexes avoid sequestration in liver, track to myriad pathologies, but do not distribute to tissues/organs with normal vascular barriers
Following cell uptake, the peptide moiety itself facilitates rapid and complete endosomal escape and KRAS siRNA release into cytoplasm to inhibit KRAS production
Peptide-nucleotide polyplexes are safe and stable in circulation, cleared by the kidney, and are not immunogenic after serial dosing
