Epigenetic Approaches to Modulate the RAS Pathway

Time: 2:30 pm
day: Day Two Track E


  • The development of kinase inhibitor resistance through epigenetic adaptation is mediated by the persistence of a small population of cells that overcome initial drug exposure
  • By selectively targeting the epigenetic mechanisms of cell survival during the early stages of drug response, durable responses to kinase inhibitors may be obtained by preventing the outgrowth of drug-resistant clones
  • Epigenetics mechanisms are able to rewire kinase signaling in several tumor models in a way that broadly suppressed the activity of other kinases and feedback loops in the RTK-RAS-MEK and Pi3K pathways