Chemical Strategies for the Mutant-Specific Targeting of RAS-Driven Cancer

Time: 5:30 pm
day: Day One Track G

Details:

  • New covalent chemistry enables mutant specific targeting of Ras mutants beyond G12C
  • The switch II pocket can be access in both GDP- and GTP-bound states
  • Chemo-immunological approach overcomes resistance to small molecule KRAS G12C inhibitors 

Speakers: